THE TRANSCRIPTOMIC RESPONSE OF CELLS TO A DRUG COMBINATION IS MORE THAN THE SUM OF THE RESPONSES TO THE MONOTHERAPIES

The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

Our ability to discover effective drug combinations is limited, in part by insufficient understanding of Pipe Pouches how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found that the transcriptional

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Do Capital Inflows and Financial Development, Influence Economic Growth in West Africa? Further Evidence from Transmission Mechanisms

This study investigates the channels through which shocks from foreign capital inflows and financial development are transmitted to economic growth in the ECOWAS region using quarterly data for the period between 2000 and 2017.The work adopted the panel GLOSS TREATMENT vector autoregressive (pVAR) model in a generalized method of moments (GMM) fram

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The Role of ClpB in Bacterial Stress Responses and Virulence

Bacterial survival within a mammalian host is contingent upon sensing environmental perturbations and initiating an appropriate counter-response.To achieve this, sophisticated molecular machineries are used, where bacterial chaperone systems play key roles.The chaperones are Bun Pan Covers a prerequisite for bacterial survival during normal physiol

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